EndoCalcMETABOLIC REFERENCE TOOLSHOMA1 vs HOMA2
THE ENDOCRINE TOOLKIT

Make sense of your
metabolic numbers.

Fasting insulin, glucose and HbA1c—connected through transparent calculators, practical explanations and original research.

01 Explicit units02 Visible formulas03 Linked evidence
A clear distinction: the calculator below uses HOMA1. HOMA2 is a separate computer model. Compare the models →
01 / START HERE

HOMA-IR calculator

Use paired fasting glucose and insulin.
Every result includes its assumptions.

Enter laboratory values

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Fields are blank until you enter values or load the example.

Used only for pmol/L inputs. Follow your laboratory’s convention.

Sampling conditions
02 / THE TOOLKIT

One place. 10 useful tools.

Browse calculators →
UNDERSTAND THE NUMBER

A result needs context.

HOMA-IR is an estimate. The assay, fasting conditions and the model all matter when interpreting it.

Read the interpretation guide →
  1. Check the sample.Paired fasting values are essential.
  2. Check the model.HOMA1 and HOMA2 results differ.
  3. Check the context.No single HOMA cutoff applies to everyone.
03 / GO A LITTLE DEEPER

Understand the tests.

All learning guides →
04 / COMMON QUESTIONS

Before you interpret a score.

All 45 answers →
What is a normal HOMA-IR level?

There is no universal normal cutoff. Assays and study populations differ; use an appropriate laboratory or research reference with clinical interpretation.

Source: Oxford HOMA calculator and FAQs (opens in a new tab) · Related calculator → · Link to answer

What is the difference between HOMA1 and HOMA2?

HOMA1 uses simple approximation equations. HOMA2 uses an iterative computer model; its results cannot be reproduced by relabelling the HOMA1 equations.

Source: Oxford HOMA calculator and FAQs (opens in a new tab) · Related calculator → · Link to answer

Can I calculate HOMA-IR with C-peptide?

C-peptide cannot replace insulin in the HOMA1 equation. Oxford’s HOMA2 software supports C-peptide within its own model and documented conditions.

Source: Oxford HOMA calculator and FAQs (opens in a new tab) · Related calculator → · Link to answer

Does a high HOMA-IR diagnose diabetes?

No. Diabetes assessment uses established glucose and A1C tests, sometimes with repeat confirmation. HOMA-IR alone is not a diagnostic criterion.

Source: NIDDK · Diabetes tests and diagnosis (opens in a new tab) · Related calculator → · Link to answer